Effect of thymosin alpha1 on immunological function and metabolism in peritoneal sepsis rats.
- Author:
Jun JIANG
1
;
Ning LI
;
Jie-Shou LI
Author Information
- Publication Type:Journal Article
- MeSH: Adjuvants, Immunologic; pharmacology; Animals; C-Reactive Protein; metabolism; Disease Models, Animal; Interleukin-10; blood; Interleukin-6; blood; Peritonitis; drug therapy; immunology; metabolism; Rats; Rats, Sprague-Dawley; Sepsis; drug therapy; immunology; metabolism; T-Lymphocyte Subsets; immunology; Thymosin; analogs & derivatives; pharmacology; Tumor Necrosis Factor-alpha; metabolism
- From: Chinese Journal of Surgery 2004;42(22):1377-1380
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of thymosin alpha1 on immunological function and protein metabolism in peritoneal sepsis rats.
METHODSWe observed the effect of thymosin alpha1 on T cell subclassification, TNFalpha, IL-6, IL-10, albumin, C-reactive protein (CRP) and mortality in cecal ligation and puncture (CLP) induced septic rats.
RESULTSConcentration of TNFalpha and IL-6 in CLP induced septic rats increased significantly, and concentration of IL-10 decreased significantly compared to control group. Thymosin alpha1 significantly decreased TNFalpha, IL-6, and significantly raised concentration of plasma IL-10, percent of CD(3), CD(4), and CD(4)/CD(8) in septic group. Thymosin alpha1 reduced degressive degree of albumin. Concentration of CRP increased in both septic groups, but was less prominently in thymosin alpha1 treated group. Thymosin alpha1 reduced cumulate 7-day mortality.
CONCLUSIONThymosin alpha1 can improve immunological function, inflammation condition and protein metabolism.
