Association of the Catechol O-Methyltransferase Val158-Met Polymorphism and Reduced Interference Control in Korean Children with Attention-Deficit Hyperactivity Disorder.
- Author:
Subin PARK
1
;
Jong Eun PARK
;
Hee Jeong YOO
;
Jae Won KIM
;
Jae Hoon CHEONG
;
Doug Hyun HAN
;
Yeni KIM
;
Bung Nyun KIM
Author Information
- Publication Type:Brief Communication
- Keywords: Attention-deficit hyperactivity disorder; COMT
- MeSH: Alleles; Catechol O-Methyltransferase*; Child*; Hospitals, University; Humans; Korea; Parents
- From:Psychiatry Investigation 2015;12(4):563-565
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: We tested for association of the catechol-O-methyltransferase (COMT) Val158-Met (rs4680) polymorphism with attention-deficit hyperactivity disorder (ADHD) using family-based test in Korean trios. METHODS: A total of 181 subjects with ADHD along with both of their biological parents were recruited from University Hospitals in Korea. We performed a transmission disequilibrium test (TDT) on 181 trios. RESULTS: In the TDT, we found the over-transmission of the Val allele in children with ADHD (chi2=4.21, p=0.040). CONCLUSION: These results suggest that the COMT Val158-Met polymorphism is associated with ADHD among the Korean population. However, this study must be replicated in larger populations.
