Bioinformatics research on chronic superficial gastritis of Pi-deficiency syndrome by gene arrays.
- Author:
Yu-long CHEN
1
;
Wei-wen CHEN
;
Ying-fang WANG
;
Ru-liu LI
;
Wen-feng GUO
;
Shao-Xian LAO
;
Jian-hua WANG
;
Sui-ping HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Chronic Disease; Cluster Analysis; Computational Biology; Gastritis; genetics; Humans; Oligonucleotide Array Sequence Analysis; Syndrome
- From: Chinese journal of integrative medicine 2009;15(5):341-346
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo determine the bioinformatical characteristics of differential gene expression in patients with chronic superficial gastritis (CSG) with the Pi-deficiency syndrome (PDS) and those of the non-Pi-deficiency syndrome (non-PDS), i.e. patients of CSG with Pi-Wei dampnese-heat syndrome and healthy persons.
METHODSWith the BRB-Array Tools software package, original data collection and bioinformatic: analysis of gene arrays were conducted in 6 CSG patients of PDS (CSG-PDS), 6 CSG patients of non-PDS (CSG-nPDS), and 6 healthy volunteers (Normal).
RESULTSCompared with non-PDS, the gene expressions: in PDS with regards to protein synthesis, energy metabolism, immune reaction and ionic transport tended to be down-regulated, while those concerning secretion, cytoskeleton and ubiquitinization were up-regulated dominantly.
CONCLUSIONSThe two kinds of samples, CSG-PDS/Normal and CSG-PDS/CSG-nPDS, have their respective gene expression profiles with different characteristics. Gene expression profile has certain referential significance in syndrome classification.
