Short-term effect of combined therapy with Jinlong Capsule and transcatheter arterial chemoembolization on patients with primary hepatic carcinoma and its influence on serum osteopontin expression.
- Author:
Guo-lin WU
1
;
Li ZHANG
;
Tian-yi LI
;
Jiu CHEN
;
Guo-you YU
;
Jian-ping LI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Antineoplastic Agents, Phytogenic; administration & dosage; Capsules; Carcinoma, Hepatocellular; blood; metabolism; therapy; Catheterization, Peripheral; methods; Chemoembolization, Therapeutic; methods; Combined Modality Therapy; Drugs, Chinese Herbal; administration & dosage; Enzyme-Linked Immunosorbent Assay; Female; Humans; Liver; blood supply; Liver Neoplasms; blood; metabolism; therapy; Male; Middle Aged; Osteopontin; analysis; blood; metabolism; Time Factors; Treatment Outcome
- From: Chinese journal of integrative medicine 2010;16(2):109-113
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo observe the clinical combination effect of Jinlong Capsule (JLC) and transcatheter arterial chemoembolization (TACE) on the patients with primary hepatic carcinoma (PHC) and JLC' s influence on serum osteopontin (OPN) expression and elucidate the correlation between the serum OPN level and curative effect of JLC and TACE.
METHODSA total of 98 patients with PHC were observed in a randomized controlled trial (RCT). They were assigned to the Chinese medicine (CM) group (53 patients who were treated with TACE and JLC) and the intervention group (45 patients who were treated with TACE only). The serum OPN levels were measured before and after treatment by quantitative sandwich enzyme-linked immunosorbent assay (ELISA). Forty healthy people were assigned to the control group. The clinical efficacy was observed and Karnofsky score (KPS) was graded.
RESULTSThe clinical efficacy of the CM group (60.38%) was better than that of the intervention group (40.00 %), and the KPS (84.35+/-12.19) was higher than the intervention group (69.86+/- 11.58) (P<0.05). The serum OPN levels before and after treatment in the patients with PHC were significantly elevated compared with those in the control group (P<0.01). After treatment, the OPN levels in CM group (117.69 <+/-78.50) were significantly lower compared with those in intervention group (151.09+/-83.90, P<0.05). The OPN levels of responders were remarkably lowered than the non-responders after treatment, and the level of OPN in the CM group was lower than the intervention group (P<0.05).
CONCLUSIONSThe short-term clinical efficacy and the quality of life of patients with PHC can be improved by combining JLC with TACE. The serum OPN levels in PHC patients can reflect the curative effect of treatment and the prognosis of the disease.
