Lectin-like oxidized low-density lipoprotein receptor-1: protein, ligands, expression and pathophysiological significance.

Xiu-ping Chen; Guan-hua DU

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Lectin-like oxidized low-density lipoprotein receptor-1: protein, ligands, expression and pathophysiological significance.

Author: Xiu-ping CHEN ¹ ; Guan-hua DU
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1. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Publication Type:Journal Article
MeSH: Animals; Arthritis, Rheumatoid; etiology; Atherosclerosis; etiology; Humans; Ligands; Myocardial Infarction; etiology; Osteoarthritis; etiology; Scavenger Receptors, Class E; chemistry; genetics; physiology
From: Chinese Medical Journal 2007;120(5):421-426
CountryChina
Language:English
Abstract:
OBJECTIVETo review the recent research progress in lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) including its protein, ligands, expression and pathophysiological significance. Data sources Information included in this article was identified by searching of PUBMED (1997 - 2006) online resources using the key term LOX-1.
STUDY SELECTIONMainly original milestone articles and critical reviews written by major pioneer investigators of the field were selected.
RESULTSThe key issues related to the LOX-1 protein as well as ligands for LOX-1. Factors regulating the expression of LOX-1 were summarized. The pathophysiological functions of LOX-1 in several diseases were discussed.
CONCLUSIONSIdentification of LOX-1 and a definition of its biological role in pathophysiologic states provide deeper insight into the pathogenesis of some cardiovascular diseases especially in atherosclerosis and provide a potential selective therapeutic approach. LOX-1 is unlocking and drugs targeting LOX-1 might be a promising direction to explore.