Effect of Jingang Jiangu pill (see text) on expression of integrin beta1 and alphavbeta3 in ovariectomized osteoporosis model rats.
- Author:
Shao-Feng YANG
1
;
Ling-Hui LI
;
Qing CHEN
;
Gong-He YAO
;
Bo DENG
;
Jian-Feng XIANG
;
Ying NIE
;
Zhen-Hua LUO
;
Yan-Tao GUO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Bone Density; Disease Models, Animal; Female; Integrin alphaVbeta3; analysis; Integrin beta1; analysis; Medicine, Chinese Traditional; Osteoporosis; drug therapy; metabolism; Ovariectomy; Rats; Rats, Wistar
- From: China Journal of Orthopaedics and Traumatology 2013;26(2):138-141
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the regulatory effect of Jingang Jiangu pill (see text, JGJG) on expression of integrin in ovariectomized rats.
METHODSFifty ovariectomized 10 months old female rats were randomly divided into 5 groups: Fushanmei group (FSM), Jingang Jiangu pill (see text) group (JGJG), Gusongbao granule group (GSB), Model group (OVX), Sham group. After ovariectomized,the rats were raised in the same environment for 13 weeks. The rats in JGJG group took 0.13 g JGJG pill orally each day for each rat; the rats in GSB group took 0.86 g GSB granule orally each day for each rat; the rats in FSM group took 0.28 mg FSM orally each day for each rat; and the rats in OVX and sham groups took sodium. The treatment duration of rats in above 5 groups was 13 weeks. Bone mineral density (BMD) and the expression of integrin beta1 and alphavbeta3 were detected in each group after the treatment. RESYKTS: The BMD and the expression of integrin beta1 in FSM group, JGJG group and GSB group improved obviously than that of OVX group. There were statistical difference between these groups (P<0.05). The expression of integrin alphavbeta3 of the three treating groups significantly depressed.
CONCLUSIONThe JGJG pill improves BMD and express of integrin beta1, in ovariectomized rats and reduces express of integrin alphavbeta3 through the regulation of the coupling of osteoblasts and osteoclasts.