Effect of Chuanxiong Fangfeng Baizhi prescription on isolated rabbit basilar artery.
- Author:
Li LI
1
;
Hongjun YANG
;
Yongqing XIAO
;
Cun ZHANG
;
Yongyan WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Apiaceae; chemistry; Basilar Artery; drug effects; physiology; Drugs, Chinese Herbal; pharmacology; In Vitro Techniques; Male; Prescriptions; Rabbits; Vasodilation; drug effects
- From: China Journal of Chinese Materia Medica 2009;34(11):1415-1417
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effect of the main constituents and its combination from Chuanxiong Fangfeng Baizhi prescription on isolated rabbit basilar artery.
METHODThe isolated rabbit basilar artery rings were treated with 5 mmol x L(-1) KCl and 5-HT 2.4 x 10(-8) mol x L(-1), and by measuring the tension of basilar artery rings, the effect of the main constituents and its combination from Chunxiong Fangfeng Baizhi Prescription on vascular activity was observed.
RESULTUnder pre-contractions of KCl 45 mmol x L(-1), ligustilide, ferulic acid, imperatorin and two constituent's combination have the vasodilatation effect on rabbit basilar artery rings white prim-o-glucosylcimifugin and 4'-O-beta-D-glucosyl-5-o-methylvisamminol have no same action. The EC50 sequence is P2 < imperatorin < ligustilide < P1 (P < 0.05). And the same vasodilatation effect on rabbit isolated basilar artery rings evoked by 5-HT 2.4 x 10(-8) mol x L(-1) was found for two constituents' combination.
CONCLUSIONExcept prim-o-glucosylcimifugin and 4'-O-beta-D-glucosyl-5-o-methylvisamminol, all samples have the vasodilatation effect on rabbit isolated basilar artery rings evoked by KCl and 5-HT, the vasodilatation effect of constituent's combination were better than any single constituent.
