Protective effect of 3'-methoxy puerarin on cerebral ischemic injury/ reperfusion in rats.
- Author:
Jin HAN
1
;
Haitong WAN
;
Lijun GE
;
Zhenhong ZHU
;
Ying GUO
;
Yuyan ZHANG
;
Jinhui LI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Brain Ischemia; drug therapy; prevention & control; Disease Models, Animal; Female; Humans; Isoflavones; pharmacology; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; drug therapy; prevention & control
- From: China Journal of Chinese Materia Medica 2009;34(11):1422-1425
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effect of 3'-methoxy puerarin on cerebral infarction volume and free radical change of focal cerebral ischemia-reperfusion injury in rats and discuss the protective effect of 3'-methoxy puerarin on the cerebral ischemic/ reperfusion injury.
METHODThe thread method was used to induce middle cerebral artery embolization, to establish the focal cerebral ischemia-reperfusion model. Rats were divided into five groups: the sham and model group, the two-dose group (5, 10 mg x kg(-1) x d(-1)) of 3'-methoxy puerarin and nimodipine group (5 mg x kg(-1) x d(-1)). The behavior changes and volume of cerebral infarction were observed, and the leves of SOD and the content of MDA were measured.
RESULT3'-methoxy puerarin could significantly improve the symptoms of neurological deficit and reduce the infarct volume, and increased SOD activity and reduced the content of MDA of cortex in cerebral ischemia-reperfusion injury rat, the action of 10 mg x kg(-1) of 3'-methoxy puerarin is more remarkable.
CONCLUSION3'-methoxy puerarin has protective effect on focal cerebral ischemia-reperfusion injury in rat.
