Development of Silymarin nanocrystals lyophilized power applying nanosuspension technology.
- Author:
Xiaoyu ZHAO
1
;
Guohua WANG
;
Baoxian ZHANG
;
Hui LI
;
Qixia NIE
;
Chen ZANG
;
Xiaomei ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: Chemistry, Pharmaceutical; methods; Freeze Drying; Nanoparticles; chemistry; Particle Size; Silymarin; chemistry; Solubility; Suspensions; chemistry
- From: China Journal of Chinese Materia Medica 2009;34(12):1503-1508
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo prepare silymarin nanosuspension and lyophilized power for enhancing the dissilution of poorly soluble drugs.
METHODThe precipitation technique was adapted to produce the silymarin nanosuspensions respectivly applying Tween 80, SDS and Poloxamer188 as stabilizers. The lyophilized formula contained 5% mannitol as cryoprotectant. Particle size, Polydispersity index and Zeta potential were detected by Mastersizer nano ZS (Malvern England). Morphological character was observed with Transmission Electron Microscopy. The product's structure was performed with X-ray diffractometer.
RESULTThe silymarin nanosuspension was successfully prepared, in which the drug particle size was about 100-300 nm,and the particles had ball-like shape and good dispersive properties.
CONCLUSIONThis study provided potential for the neotype dosage form development of the Chinese Traditional Medicine.
