Metabolic study of ginsenoside Re in rats.
- Author:
Guangtong CHEN
1
;
Min YANG
;
Dean GUO
Author Information
- Publication Type:Journal Article
- MeSH: Administration, Oral; Animals; Biotransformation; Feces; chemistry; Ginsenosides; analysis; metabolism; Male; Rats; Rats, Sprague-Dawley
- From: China Journal of Chinese Materia Medica 2009;34(12):1540-1543
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo systemically study the metabolism of ginsenoside Re in rats.
METHODSix SD rats were used divided into 3 groups. After oral administration of ginsenoside Re at a dosage of 100 mg x kg(-1), feces were collected at 12, 24, 36, 48, and 60 h. The microbial transformation metabolites of ginsenoside Re were used as standard references. HPLC-ESI-MS/MS analysis was used in the metabolism studies.
RESULTSix metabolites of ginsenoside Re were detected in rat feces by HPLC-ESI-MS/MS analysis. Their structures were identified as 20(S)-ginsenoside Rg2, 20(S)-ginsenoside Rh1, 20(R)-ginsenoside Rh1, ginsenoside F1, 3-oxo-ginsenoside Rh1 and protopanaxatriol.
CONCLUSIONGinsenoside Re has the same metabolic pathway with microorganisms, to some extent, justified the use of microbial models for mammalian metabolism studies.
