Anti-tumor activity and mechanism with SSCE of Spatholobus suberctus.
- Author:
Qi FU
1
;
Yong TANG
;
Xiaoqin LUO
;
Guowang YANG
;
Wei HE
;
Xiaomin WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antineoplastic Agents; pharmacology; therapeutic use; Carcinoma, Lewis Lung; drug therapy; physiopathology; Cell Cycle; drug effects; Cell Line, Tumor; Cell Proliferation; drug effects; Disease Models, Animal; Fabaceae; chemistry; Humans; Lung Neoplasms; drug therapy; physiopathology; Male; Mice; Mice, Inbred C57BL; Plant Extracts; pharmacology; therapeutic use
- From: China Journal of Chinese Materia Medica 2009;34(12):1570-1573
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effect of anti-tumor and mechanism of the extract of Spatholobus suberctus (SSCE) in vivo.
METHODThe mouse model of Lewis lung carcinoma was used to investigate the effects of SSCE on tumor growth and metastasis. Furthermore, we explored the mechanism of anti-tumor by analyze the cell cycle and determine the apoptosis.
RESULTThe studies demonstrated that the tumor inhibitory rate of SSCE in low dose group was the highest (30.65%) on Lewis lung cancer. SSCE can resist metastasis, at the same time, it can induce cell cycle arrested in G1 phase, whereas, there was no significant difference in apoptotic rate each group.
CONCLUSIONWe verified that SSCE exits anti-tumor effect and resist metastasis, furthermore, it can arrest function cell in G1 phase.
