Protection on myocardial ischemia and reperfusion injury by Salvia miltiorrhiza hairy root in isolated Langendorff rat hearts.
- Author:
Lan WANG
1
;
Dongmei LV
;
Rixing LIANG
;
Luqi HUANG
;
Yuan YUAN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Disease Models, Animal; Heart; drug effects; In Vitro Techniques; Male; Myocardial Ischemia; drug therapy; metabolism; Myocardial Reperfusion Injury; drug therapy; metabolism; Myocardium; metabolism; Plant Extracts; pharmacology; Plant Roots; chemistry; Protective Agents; pharmacology; Rats; Rats, Wistar; Salvia miltiorrhiza; chemistry
- From: China Journal of Chinese Materia Medica 2009;34(14):1848-1851
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEProtection by Salvia miltiorrhiza hairy root on myocardial ischemia and reperfusion injury in isolated Langendorff rat hearts was observed.
METHODIsolated rat hearts were perfused with 14, 28, 56 mg x L(-1) for 10 min followed by a 10 min washout period before the induction of 30 min normothermic global ischemia and 60 min of reperfusion.
RESULTOur results showed that S. miltiorrhiza hairy root reduced the incidence of reperfusion-induced VF and VT and delayed the onset time of VF and VT. The increased aortic flow and content of SOD with decreased release of LDH and MDA were found.
CONCLUSIONOur results show that S. miltiorrhiza hairy root can prevent postischmic abnormalities in reperfusion arrhythmias, aortic flow and myocardium metabolism, which was similar to actions of S. miltiorrhiza.
