A novel clinicopathological analysis of early stage ovarian Sertoli-Leydig cell tumors at a single institution.
- Author:
Seon Mi NAM
1
;
Jee Whan KIM
;
Kyung Jin EOH
;
Hye Min KIM
;
Jung Yun LEE
;
Eun Ji NAM
;
Sunghoon KIM
;
Sang Wun KIM
;
Young Tae KIM
Author Information
- Publication Type:Original Article
- Keywords: Drug therapy; Histology; Ovarian neoplasms; Sertoli-Leydig cell tumor
- MeSH: Bleomycin; Carcinoma, Endometrioid; Chemotherapy, Adjuvant; Child; Cisplatin; Diagnosis; Drug Therapy; Etoposide; Female; Gynecology; Humans; Hysterectomy; Lymph Node Excision; Medical Records; Obstetrics; Ovarian Neoplasms; Paclitaxel; Prognosis; Recurrence; Sertoli-Leydig Cell Tumor*
- From:Obstetrics & Gynecology Science 2017;60(1):39-45
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: To evaluate the clinical and pathologic characteristics of patients who were diagnosed with ovarian Sertoli-Leydig cell tumors (SLCTs) in a single institution. METHODS: The medical records of 11 patients who were pathologically diagnosed with SLCTs beginning in 1995 in a single institute was reviewed. RESULTS: The median patient age was 31 years (range, 16 to 70 years). Patient International Federation of Gynecology and Obstetrics stages were IA, IC, and IIB in 3 (27.3%), 6 (54.5%), and 2 (18.2%) patients, respectively. Six patients (54.5%) had grade 3 tumors, 3 patients (27.3%) had grade 2 tumors, and 1 patient (9.1%) had a grade 1 tumor. Four patients without children underwent fertility-sparing surgery, and 7 patients had full staging surgery, including a hysterectomy and bilateral salpingo-oophorectomy, with a laparoscopic approach used in 3. Eight patients underwent pelvic lymph node dissection, and 8 patients were administered adjuvant chemotherapy consisting of bleomycin, etoposide, and cisplatin in 6 cases, a modified bleomycin, etoposide, and cisplatin regimen in 1 case, and a combined paclitaxel and cisplatin regimen in 1 case. Two patients died of disease and were re-diagnosed with Sertoli form endometrioid carcinoma. The other patients remain alive without recurrence at the time of reporting. CONCLUSION: Our findings suggest that regardless of tumor stage or grade, ovarian SLCT patients have a good prognosis. Close observation and unilateral salpingo-oophorectomy would be beneficial for women who still wish to have children, while hysterectomy and bilateral salpingo-oophorectomy with adjuvant chemotherapy would be the optimal treatment in other cases. Furthermore, meticulous pathologic diagnosis is needed to develop a precise treatment strategy.
