Effect of preoperative transcatheter arterial chemo-embolization on activity of cell proliferation in Wilms; tumor.
- Author:
Wei-guang LIU
1
;
Wei-zhong GU
;
Yin-bao ZHOU
;
Hong-feng TANG
;
Min-ju LI
Author Information
- Publication Type:Journal Article
- MeSH: Cell Proliferation; Chemoembolization, Therapeutic; adverse effects; Child; Child, Preschool; Female; Humans; Infant; Kidney Neoplasms; therapy; Male; Preoperative Care; Proliferating Cell Nuclear Antigen; metabolism; Vascular Endothelial Growth Factor A; metabolism; Wilms Tumor; complications; pathology; surgery; therapy
- From: Journal of Zhejiang University. Medical sciences 2008;37(1):83-87
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of preoperative transcatherter arterial chemo-embolization (TACE) on the cell proliferation in Wilms; tumor.
METHODSForty-one cases of Wilms; tumor diagnosed by histopathology were divided into two groups: in TACE group, 23 patients received TACE first and were operated 2 weeks later; in control group, 18 patients were operated alone. A comparative analysis of the pathological finding was made in two groups, and the expression of PCNA and VEGF in tumor tissue was detected by immunohistochemistry.
RESULTThe degeneration of tumor tissue such as tumor cell necrotic, broken, disappearance occurred in 17 cases of TACE group and in 4 cases of control group, respectively (P <0.01). The expression of PCNA in TACE group and in control group was 1/23 (4.3 %) and 9/18(50.0 %), respectively (P <0.01). VEGF was expressed in 7/23 (30.4 %) of TACE group and 9/18 (50.0 %) of control group (P=0.283).
CONCLUSIONTACE can significantly inhibit proliferation and enhance degeneration of Wilms; tumor cells.
