Determination of dimethyl sulphate residual in granisetron hydrochloride by headspace gas chromatography.

Author: Gui-feng DENG ¹ ; Tong-wei YAO
Author Information

1. Department of Pharmaceutical Analysis and Drug Metabolism, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Publication Type:Journal Article
MeSH: Chromatography, Gas; methods; Drug Contamination; prevention & control; Granisetron; analysis; Pharmaceutical Preparations; analysis; Sulfuric Acid Esters; analysis
From: Journal of Zhejiang University. Medical sciences 2008;37(2):156-158
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo develop a headspace gas chromatography method for determining dimethyl sulphate residual in granisetron hydrochloride.
METHODSAn Angilent INNOWAX capillary column with nitrogen gas as carrier and FID as detector was applied in this study. Dimethyl sulphate was tested under a constant column temperature.
RESULTDimethyl sulphate had different retention time from other organic solvents such as alcohol,acetoacetate, isopropanol, dichlormethane and chloroform, which might exist in granisetron hydrochloride. The detection limit of dimethyl sulphate;s was 0.0016%.
CONCLUSIONThe method can be used for the determination of dimethyl sulphate residual in granisetron hydrochloride.