Interaction of cancer-associated fibroblasts and tumor cells in carcinogenesis.
- Author:
Jian WU
1
;
Hong DENG
Author Information
1. Department of Pathology, College of Medicine, Zhejiang University, Hangzhou 310058, China.
- Publication Type:Journal Article
- MeSH:
Cell Communication;
Cell Transformation, Neoplastic;
pathology;
Disease Progression;
Epithelial Cells;
pathology;
Fibroblasts;
pathology;
Humans;
Myoblasts;
pathology;
Neoplasms;
pathology;
physiopathology
- From:
Journal of Zhejiang University. Medical sciences
2008;37(2):212-217
- CountryChina
- Language:Chinese
-
Abstract:
Tumor microenvironment is composed of mesenchymal cells and extracellular matrix components, which plays an important role in the growth, invasion and metastasis of tumor cells. Characteristic changes of stroma are usually accompanied with the malignant transformation of epithelial cells even ahead. The key component in the process-activated fibroblasts, also known as myofibroblasts, or cancer-associated fibroblasts (CAF), is the most abundant cells in tumor stroma. They promote the malignant transformation of epithelial cells through cell-cell communication via various soluble factors. This article reviews cancer-associated fibroblasts and their role in tumor development.
