Effect of morphine chloride on contractility of small intestinal muscle in vitro or in vivo and its mechanisms.
- Author:
Zhi-Ying FENG
1
;
Lian-Gen MAO
;
Yuan LU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Female; Gastrointestinal Transit; drug effects; In Vitro Techniques; Intestine, Small; drug effects; Male; Mice; Morphine; pharmacology; Muscle Contraction; drug effects; Muscle, Smooth; drug effects; Rabbits
- From: Journal of Zhejiang University. Medical sciences 2008;37(3):271-275
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of morphine chloride on small intestinal muscle in vitro or in vivo and its mechanisms.
METHODSContractile amplitude, tension and frequency of the isolated small intestine of rabbits were measured before and after treatment of morphine chloride. The propulsive distance of magenta in intestinal tract was measured when different concentration of morphine chloride was given orally in mice.
RESULTAfter treatment of different concentration of morphine chloride (5 mg/L, 10 mg/L, 30 mg/L), the contractile activities of isolated small intestines of rabbits decreased significantly. The inhibitory effect of morphine chloride was blocked by naloxone, atropine, but potentiated by regitine. The propulsive distance of magenta in intestinal tract of intact mouse decreased after treatment with morphine chloride of various concentration (75, 150, 300 mg/L).
CONCLUSIONMorphine chloride has an inhibitory effect on the contractility of rabbit small intestine in vitro or in vivo. Opioid receptor, choline and adrenal receptor might be involved in this effect.
