Comparison of midazolam and propofol as conscious sedation in oocyte retrieval of IVE-ET.
- Author:
Yuan-Ying MA
1
;
Yan SHEN
;
Li-San ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Anesthetics, Combined; administration & dosage; Anesthetics, Intravenous; administration & dosage; Female; Fentanyl; administration & dosage; Fertilization in Vitro; Humans; Midazolam; administration & dosage; Oocyte Retrieval; methods; Propofol; administration & dosage
- From: Journal of Zhejiang University. Medical sciences 2008;37(3):304-307
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo compare the efficacy and safety of midazolam combined with fentanyl and propofol combined with fentanyl as conscious sedation in oocyte retrieval of in vitro fertilization and embryo transplantation (IVF-ET).
METHODSEighty patients receiving IVE-ET were randomly divided into midazolam combined with fentanyl group (midazolam group) and propofol combined with fentanyl group (propofol group). Antalgic effects, circulation status (blood pressure, heart rate), respiration status (rate, oxygen saturation and respiration depression) during operation, nausea and vomiting, and amnestic effects after operation were compared.
RESULTNo differences of antalgic effects and circulation status between two groups were observed. Percentages of respiration depression,vomiting and amnesia of midazolam group were 5.0 %, 10.0 % and 25%, respectively, and those of propofol group were 25%, 27.5% and 7.5%, respectively, which had statistical significance.
CONCLUSIONAs conscious sedation, midazolam combined with fentanyl is better than propofol combined with fentanyl in oocyte retrieval of IVF-ET.
