Protective effects of edaravone on renal ischemia-reperfusion injury in rats.
- Author:
Ge ZHANG
1
;
Qiu-ping XU
;
Hai-ying HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antipyrine; analogs & derivatives; therapeutic use; Kidney; blood supply; Male; Malondialdehyde; metabolism; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; metabolism; prevention & control; Superoxide Dismutase; metabolism
- From: Journal of Zhejiang University. Medical sciences 2008;37(3):308-311
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of edaravone on renal ischemia-reperfusion injury in rats.
METHODSFifty rats were randomly divided into five groups: sham operation group (Group A), renal ischemia-reperfusion group (Group B) and edaravone treated groups (Group C1, Group C2 and Group C3 with different drug dosages). Serum maleic dialdehyde (MDA) and superoxide dismutase (SOD), renal MDA and SOD, serum creatinine (Cr), blood urea nitrogen (BUN) were measured after the rat kidney was ischemia-reperfused for 24 hours. Renal ultrastructure was observed.
RESULTCompared with Group A, serum and renal MDA, serum Cr, BUN of Group B were significant increased (P <0.01), serum and renal SOD of Group B were significant decreased (P <0.01). After edaravone treatment, serum MDA, Cr and renal MDA of Group C were lower than those in Group B (P<0.01); Serum and renal SOD of group C were higher than those in Group B (P <0.01); Compared with Group B, BUN level of Group C had no significant change (P >0.05). The renal ultrastructure was greatly injured in Group B, meanwhile it was obviously ameliorated in Group C.
CONCLUSIONEdaravone has protective effects on renal ischemia-reperfusion injury in rats.
