Progress in genetic research on psoriatic arthritis.
10.3760/cma.j.issn.1003-9406.2017.04.030
- Author:
Yan JU
1
;
Erle DANG
;
Chunxiang YANG
;
Hongping SONG
Author Information
1. Department of Ultrasonography, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710032, China. 371956@qq.com.
- Publication Type:Journal Article
- MeSH:
Arthritis, Psoriatic;
genetics;
Genetic Predisposition to Disease;
genetics;
Genetic Research;
Humans;
Polymorphism, Single Nucleotide;
genetics;
Psoriasis;
genetics
- From:
Chinese Journal of Medical Genetics
2017;34(4):606-610
- CountryChina
- Language:Chinese
-
Abstract:
Psoriatic arthritis is a form of inflammatory arthritis found among patients with psoriasis, which can lead to pain, swelling or stiffness in one or more joints and even movement disorders. Epidemiological studies have shown a higher heritability for psoriatic arthritis compared with psoriasis vulgaris. With the evolvement of DNA sequencing, many genes have been associated with psoriasis vulgaris and psoriatic arthritis, which included MHC, TNF, LCE, IL23R, IL12B, TRAF3IP2 and TNFAIP3, though some, such as MHC, IL-13 and PTPN22, have been specifically associated with psoriatic arthritis. These studies have laid a foundation for risk prediction, diagnosis and drug development for psoriatic arthritis.
