Application of array comparative genomic hybridization analysis for fetuses with growth anomalies.

Author: Lin WANG ¹ ; Xiaobin WANG ; Na CAI ; Bin HE ; Qiuhua WU ; Wei LI ; Liping ZHANG ; Xiaoping MA ; Rong QIANG
Author Information

1. Center of Medical Genetics, Northwest Women and Children's Hospital, Xi'an, Shaanxi 710061, China. qiangrongshx@126.com.
Publication Type:Journal Article
MeSH: Adult; Chromosome Aberrations; Comparative Genomic Hybridization; methods; Congenital Abnormalities; genetics; DNA Copy Number Variations; Female; Humans; Pregnancy; Prenatal Diagnosis; methods
From: Chinese Journal of Medical Genetics 2017;34(5):691-694
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo explore the genetic etiology for fetuses featuring intrauterine growth anomalies using array-based comparative genomic hybridization (aCGH).
METHODSForty-nine fetuses were enrolled in this study. Genomic DNA of the abortive tissues was analyzed with aCGH.
RESULTSFourteen (28.6%) samples were found with chromosomal aberrations, which included 8 chromosomal aneuploidies and 6 micro-aberrations (4 with known clinical pathogenecity and 2 with unknown clinical significance).
CONCLUSIONNumerical and structural chromosomal aberrations underlie a significant proportion of fetal growth anomalies. aCGH has provided an effective method for delineating their genetic cause.