Association of KCNE1 and KCNE4 gene polymorphisms with atrial fibrillation among Uygur and Han Chinese populations in Xinjiang.

Haijun Miao; Xiaohui Zhou; Keyimu Kabinur; Ting Zou; Abulizi Palida; Baopeng Tang

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Association of KCNE1 and KCNE4 gene polymorphisms with atrial fibrillation among Uygur and Han Chinese populations in Xinjiang.

Author: Haijun MIAO ¹ ; Xiaohui ZHOU ; Keyimu KABINUR ; Ting ZOU ; Abulizi PALIDA ; Baopeng TANG
Author Information

1. First Department of Internal Medicine for Cadres, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China. mhjmex@163.com.
Publication Type:Journal Article
MeSH: Atrial Fibrillation; etiology; genetics; Case-Control Studies; China; ethnology; Humans; Polymorphism, Genetic; Potassium Channels, Voltage-Gated; genetics; Risk Factors
From: Chinese Journal of Medical Genetics 2017;34(5):743-748
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo assess the association of KCNE1 (rs1805127) and KCNE4 (rs12621643) polymorphisms with atrial fibrillation (AF) among ethnic Uygur and Han Chinese in Xinjiang.
METHODSA case-control study was carried out. The patients and controls were selected based on ethnicity, gender and age with an 1:1 ratio. DNA was extracted from peripheral blood samples. Genotypes of KCNE1 (rs1805127) and KCNE4 (rs12621643) were determined with a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay.
RESULTSMultivariate Logistic regression analysis showed KCNE1 (rs1805127) to be an independent risk factor for AF among Uygurs, while KCNE4 (rs12621643) was a risk factor for both Uygur and Han patients with AF (P < 0.05). The population attributable risk percentage (PARc%) of obstructive sleep apnea hpoventilation syndrome, obesity, hypertension, cholesterol, Hcy, hs-CRP, IL-6, KCNE1 (rs1805127) and KCNE4 (rs12621643) were 9.68%, 12.06%, 15.76%, 6.91%, 11.37%, 17.78%, 9.31%, 11.27% and 6.46% among the Uygurs, respectively. The PARc% of drinking, hypertension, cholesterol, Hcy, hs-CRP, IL-6, and KCNE4 (rs12621643) were 12.94%, 14.48%, 7.24%, 8.49%, 17.29%, 9.49% and 7.41% among Hans.
CONCLUSIONThe KCNE1 (rs1805127) appears to an independent risk factor for AF in the Uygur population. And the KCNE4 (rs12621643) was an independent risk factor for AF among both Uygurs and Hans. Management of the risk factors of AF based on testing of "risk genes" may have an impact on the prevention and treatment of AF.