Association of aggressive behaviors of schizophrenia with short tandem repeats loci.
- Author:
Chun YANG
1
;
Huajie BA
;
Xingqi TAN
;
Hanqing ZHAO
;
Shuyou ZHANG
;
Haiying YU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Aggression; Gene Frequency; Genotype; Humans; Microsatellite Repeats; Middle Aged; Schizophrenia; genetics; Young Adult
- From: Chinese Journal of Medical Genetics 2017;34(6):901-904
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the association of short tandem repeats (STRs) loci with aggressive behaviors of schizophrenia.
METHODSBlood samples from 123 schizophrenic patients with aggressive behaviors and 489 schizophrenic patients without aggressive behaviors were collected. DNA from all samples was amplified with a PowerPlex 21 system and separated by electrophoresis to determine the genotypes and allelic frequencies of 20 STR loci including D3S1368, D1S1656, D6S1043, D13S317, Penta E, D16S639, D18S51, D2S1338, CSF1PO, Penta D, TH01, vWA, D21S11, D7S820, D5S818, TPOX, D8S1179, D12S391, D19S433, and FGA.
RESULTSAll of the 20 STR loci have reached Hardy-Weinberg equilibrium in both groups. A significant difference was found in allelic and genotypic frequencies of loci Penta D between the two groups (alleles: P=0.042; genotypes: P=0.014) but not for the remaining 19 loci (P> 0.05). Univariate analysis also showed a significant difference for allele 10 and genotypes 10-12 of Penta D between the two groups (P=0.0027, P=0.0001), with the OR being 1.81 (95%CI: 1.22-2.67) and 4.33 (95%CI: 1.95-9.59), respectively.
CONCLUSIONPenta D may be associated with aggressive behaviors of schizophrenia. Allele 10 and genotypes 10-12 of Penta D may confer a risk for the disease.
