Effect of MTHFR gene on the schizophrenia and its cognitive function.
- Author:
Weiping WANG
1
;
Weixing FAN
;
Bo SHI
;
Chunnan TONG
;
Xiaorong WANG
;
Jun CAI
;
Chen ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Cognition; Genotype; Humans; Methylenetetrahydrofolate Reductase (NADPH2); genetics; Middle Aged; Polymorphism, Genetic; Schizophrenia; genetics; Schizophrenic Psychology; Young Adult
- From: Chinese Journal of Medical Genetics 2017;34(6):905-908
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of MTHFR gene on schizophrenia and its cognitive function.
METHODSWe recruited 254 schizophrenia patients with stable condition, 339 healthy controls for genetic analysis and 72 healthy controls for cognitive evaluation. The repeatable battery for the assessment of neuropsychological status (RBANS) was used for cognitive measurement. PCR-RFLP technique was carried out to genotype 677C/T polymorphism.
RESULTSThere were no significant differences in genotypic or allelic frequencies of the 677C/T polymorphism between the case and control groups (P> 0.05). In the RBANS, patients had higher scores of immediate memory, visuospatial skill, language, attention, delayed memory and total scores than healthy controls (P< 0.01); Patients with different genotypes of 677C/T polymorphism had significant differences in the scores of immediate memory, attention and total scores (P< 0.05).
CONCLUSIONOur results did not provide evidence for MTHFR gene conferring susceptibility to schizophrenia. However, there was a significant association between the MTHFR gene and cognitive impairment in patients with schizophrenia, especially in immediate memory and attention.
