Association of HSPA1A gene single nucleotide polymorphisms with the development of cervical cancer among ethnic Han Chinese from Yunnan.
- Author:
Xinwen ZHANG
1
;
Zhiling YAN
;
Li SHI
;
Hongying YANG
;
Chao HONG
;
Jiankun YU
;
Chuanyin LI
;
Yufeng YAO
Author Information
- Publication Type:Journal Article
- MeSH: China; ethnology; Female; Genetic Predisposition to Disease; Genotype; HSP70 Heat-Shock Proteins; genetics; Haplotypes; Humans; Polymorphism, Single Nucleotide; Uterine Cervical Neoplasms; etiology; genetics
- From: Chinese Journal of Medical Genetics 2017;34(6):909-914
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the association of four single nucleotide polymorphisms (SNPs) (rs12190359C>T, rs562047C>G, rs1008438G>T, and rs1043618G>C) of HSPA1A gene with the development of cervical cancer among ethnic Han Chinese from Yunnan.
METHODSOne hundred and thirty patients with CIN III, 444 patients with cervical cancer, and 548 healthy individuals were recruited, and the genotypes of the above SNPs were determined with a Taqman assay. Haplotypes were constructed, and their association with the development of cervical cancer was analyzed.
RESULTSThe frequencies of G and T alleles of rs1008438G>T were significant different between the CIN III and control groups, as well as between the cancer and control groups (P=0.022 and P=0.030, respectively). There was a significant difference in genotypic frequency of rs1008438G>T between the CIN III and control groups (P=0.047). The allelic and genotypic frequencies of rs12190359C>T, rs562047C>G, and rs1043618G>C did not significantly differ between the CIN III, cervical cancer and control groups (P> 0.05). The frequencies of haplotypes formed by rs562047C>G, rs1008438G>T and rs1043618G>C also did not significantly differ between the CIN III, cancer and control groups (P> 0.05).
CONCLUSIONThe G allele of rs1008438G>T may be a protective factor for cervical cancer among ethnic Han Chinese from Yunnan.
