Advance in molecular genetic research on X-linked syndromic hearing impairment.
10.3760/cma.j.issn.1003-9406.2017.06.033
- Author:
Maomin HUANG
1
;
Dingding ZHANG
Author Information
1. Department of Immunology, Zunyi Medical University, Zunyi, Guizhou 563000, China. Email: zdd25@sina.com.
- Publication Type:Journal Article
- MeSH:
Genetic Diseases, X-Linked;
genetics;
Genetic Research;
Hearing Loss;
diagnosis;
genetics;
therapy;
Humans;
Molecular Biology
- From:
Chinese Journal of Medical Genetics
2017;34(6):928-933
- CountryChina
- Language:Chinese
-
Abstract:
In addition to hearing impairment, syndromic hearing impairment is often accompanied by disorders of urinary, skeletal, muscular, nervous, and ocular systems. Genetic factors have shown to play an important role in the pathogenesis of deafness. Mutations of X-linked genes may cause syndromic hearing impairment. Gene mapping, linkage analysis and next-generation sequencing may facilitate delineation of the pathogenesis of X-linked syndromic hearing impairment. This article reviews recent progress in molecular genetic research on X-linked syndromic hearing impairment, which may shed light for the diagnosis and treatment of these diseases.
