Association of polymorphisms of KIR2DL4 gene with leukemia among ethnic Hans from southern China.
10.3760/cma.j.issn.1003-9406.2018.01.026
- VernacularTitle:KIR2DL4基因的多态性与南方汉族白血病的相关性研究
- Author:
Rui CHEN
1
,
2
;
Zhihui DENG
Author Information
1. Southern Medical University, Guangzhou, Guangdong 510515, China
2. Shenzhen Blood Center, Shenzhen, Guangdong 518035, China. Email: zhihui_deng@aliyun.com.
- Publication Type:Journal Article
- From:
Chinese Journal of Medical Genetics
2018;35(1):112-115
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To assess the association of polymorphisms of KIR2DL4 gene with leukemia among ethnic Hans from southern China. METHODS A total of 590 leukemia patients were recruited, which included 283 cases of acute lymphoblastic leukemia (ALL), 277 cases of acute myeloid leukemia (AML), and 80 cases of chronic myeloid leukemia (CML). Meanwhile, 306 healthy controls were randomly selected from volunteer blood donors. Both groups were subjected to sequence-based typing of the entire coding sequence of the KIR2DL4 gene using an in-house assay. The genotype for each sample was determined with Assign 4.7 SBT software. The frequencies of each detected KIR2DL4 allele, the 9A type KIR2DL4 allele and 10A type KIR2DL4 allele of the ALL, AML and CML groups were compared with those of the control group. RESULTS Five KIR2DL4 alleles, namely KIR2DL4*001, *005, *006, *008 and *011, were detected in the ALL, AML and CML groups as well as the control group. A significant difference was detected in the frequencies of KIR2DL4*011 and 10A type KIR2DL4 allele between the ALL group and the control group (KIR2DL4*011: OR = 1.66, P = 0.01; 10A type KIR2DL4: OR = 0.42, P = 0.03), but was lost after P correction (Pc > = 0.05). No significant difference was detected in the frequencies of KIR2DL4 alleles, the 9A type KIR2DL4 and 10A type KIR2DL4 allele between the AML and CML patient groups compared with the control group (P > 0.05, Pc > 0.05). CONCLUSION The allelic diversity of the KIR2DL4 locus showed no significant association with leukemia among ethnic Hans from southern China.
