Preparation of the oral self-microemulsifying drug delivery system of GBE50.
- Author:
Ying XIONG
1
;
Qi-De LIU
;
Le LAI
;
Jian-Hai CHEN
Author Information
1. Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
- Publication Type:Journal Article
- MeSH:
Biological Availability;
Drug Delivery Systems;
methods;
Drugs, Chinese Herbal;
administration & dosage;
chemical synthesis;
pharmacokinetics;
Ginkgolides;
administration & dosage;
chemical synthesis;
pharmacokinetics;
Technology, Pharmaceutical;
methods
- From:
Acta Pharmaceutica Sinica
2009;44(7):803-808
- CountryChina
- Language:Chinese
-
Abstract:
To prepare the oral self-microemulsifying drug delivery system (SMEDDS) of GBE50, balance solubility method was used to screen emulsifier and assistant emulsifier; a pseudo-tamary phase diagram was used to prepare microemulsion; and orthogonal design was used to optimize formulation. Self-microemulsifying efficiency, dissolution, stability and pharmacokinetics of the preparation were studied. As a result, GBE50-SMEDDS of IPM, Cremophor EL, 1,2-propanediol and GBE50 could be self emulsified to form stable microemulsion with particle diameter between 20 and 50 nm when emulsifying with water. Its self-microemulsifying efficiency and dissolution are quick with good stability and it has a higher bioavailability than market existing agents Xingling particles. GBE50-SMEDDS is stable and effective.
