A new erythrodiol triterpene fatty ester from Scorzonera mongolica.
- Author:
Bin WANG
1
;
Guo-qiang LI
;
Hua-shi GUAN
;
Li-ye YANG
;
Guo-zhong TONG
Author Information
1. School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316000, China. binwang4159@hotmail.com
- Publication Type:Journal Article
- MeSH:
Animals;
Antineoplastic Agents, Phytogenic;
chemistry;
isolation & purification;
pharmacology;
Carcinoma, Hepatocellular;
pathology;
Cell Line, Tumor;
drug effects;
Drugs, Chinese Herbal;
chemistry;
isolation & purification;
pharmacology;
Humans;
Leukemia P388;
pathology;
Liver Neoplasms;
pathology;
Lung Neoplasms;
pathology;
Magnetic Resonance Spectroscopy;
Mice;
Molecular Structure;
Plants, Medicinal;
chemistry;
Scorzonera;
chemistry;
Triterpenes;
chemistry;
isolation & purification;
pharmacology
- From:
Acta Pharmaceutica Sinica
2009;44(11):1258-1261
- CountryChina
- Language:English
-
Abstract:
Two erythrodiol triterpene fatty esters, 3beta-dodecanoyl erythrodiol (1) and 3beta-tetradecanoyl erythrodiol (2), were isolated from Scorzonera mongolica. Their structures were elucidated on the basis of IR, MS and extensive 2D NMR spectroscopic analysis. Compound 1 was identified to be a new compound and 2 was confirmed to be a new natural compound. Their antitumor effects in vitro were evaluated with MTT and SRB assays, but compounds 1 and 2 only showed moderate cytotoxicities on A-549 cell line.
