Action of protein phosphatase-1 on Tat-dependent HIV-1 transcription and its related inhibitors.
- Author:
Jun WANG
1
;
Xin-Yong LIU
Author Information
1. Institute of Medicinal Chemistry, School of Pharmacy, Shandong University, Jinan 250012, China.
- Publication Type:Journal Article
- MeSH:
Anti-HIV Agents;
pharmacology;
Enzyme Inhibitors;
pharmacology;
HIV-1;
genetics;
Humans;
Okadaic Acid;
pharmacology;
Protein Phosphatase 1;
antagonists & inhibitors;
chemistry;
physiology;
Pyrans;
pharmacology;
Spiro Compounds;
pharmacology;
Transcription, Genetic;
tat Gene Products, Human Immunodeficiency Virus;
physiology
- From:
Acta Pharmaceutica Sinica
2009;44(12):1343-1347
- CountryChina
- Language:Chinese
-
Abstract:
Host cell protein phosphatase-1 (PP1) is an important regulator of human immunodeficiency virus-1 (HIV-1) transcription. PP1 is involved in the regulation of HIV-1 transcription, and dephosphorylates RNA polymerase II C-terminal domain (RNAPII CTD) or CycT1-dependent kinase 9 (CDK9) to increase Tat-dependent HIV-1 transcription. In this review, we discuss the action of PP1 in Tat-induced HIV-1 transcription and related to PP1 inhibitors.
