Advances in the study of regulation of novel organic cation transporter-2.
- Author:
Fu-Rong WANG
1
;
Rui-Chen GUO
Author Information
1. Qilu Hospital Affiliated to Shandong University, Jinan 250012, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Biological Transport;
Carnitine;
metabolism;
Carrier Proteins;
physiology;
Clofibrate;
pharmacology;
Colitis;
metabolism;
Homeostasis;
drug effects;
Humans;
Mutation;
Organic Cation Transport Proteins;
genetics;
metabolism;
physiology;
PPAR alpha;
agonists;
RNA, Messenger;
metabolism;
Solute Carrier Family 22 Member 5
- From:
Acta Pharmaceutica Sinica
2009;44(10):1061-1065
- CountryChina
- Language:Chinese
-
Abstract:
Novel organic cation transporter-2 (OCTN2), a member of the organic cation transporter family, may transport carnitine and multiple organic cationic drugs. Thus OCTN2 possesses substantial roles in physiology and pharmacology. A number of researches have proven that many factors can regulate the expression and/or function of OCTN2 via different pathways, and then may affect the homeostasis and disposition of drugs. This paper reviews recent progresses in this field.
