A new trincallane derivative from Salacia hainanensis Chun et How.
- Author:
Zheng-Hong GUO
1
;
Rong-Gang XI
;
Xiao-Bo WANG
;
Li-Jun WU
;
Hui-Yuan GAO
Author Information
1. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
- Publication Type:Journal Article
- MeSH:
Catechin;
analogs & derivatives;
chemistry;
isolation & purification;
Molecular Structure;
Pentacyclic Triterpenes;
chemistry;
isolation & purification;
Plant Roots;
chemistry;
Plant Stems;
chemistry;
Plants, Medicinal;
chemistry;
Salacia;
chemistry;
Steroids;
chemistry;
isolation & purification;
Triterpenes;
chemistry;
isolation & purification;
Xanthones;
chemistry;
isolation & purification
- From:
Acta Pharmaceutica Sinica
2009;44(10):1123-1126
- CountryChina
- Language:Chinese
-
Abstract:
Chemical constituents of the roots and stem of Salacia hainanensis Chun et How were isolated and purified with column chromatography on silica gel, Sephadex LH-20 and preparative HPLC. Their structures were elucidated based on physicochemical and spectral spectroscopic analysis. Depending on the activities of anti-alpha-glucosidase and inhibiting AGEs (advanced glycation end products, AGEs) formation in vitro, nine compounds were identified as 26, 27-dihydroxy-7, 24-tirucalladien-3-one (1), abruslactone A (2), lupeol (3), 21alpha, 30-dihydroxy-D: A-friedooleanan-3-one (4), 15alpha-hydroxyfriedelan-3-one (5), friedelin (6), mangiferin (7), epicatechin (8) and beta-sitosterol (9), separately. Among them, compound 1 is a new compound, and compound 2 was isolated from the Salacia genus for the first time, while, compounds 3, 4, 5, 8 were obtained from this plant for the first time.
