Microcalorimetric investigation of two cephalosporins on colon bacteria activity.
- Author:
Fen XU
1
;
Cheng-Gong SONG
;
Rui-Hua WU
;
Li-Ni YANG
;
Li-Xian SUN
;
Zong-Bao ZHAO
;
Zhi-Heng ZHANG
;
Zhong CAO
;
Ling ZHANG
Author Information
1. College of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029, China.
- Publication Type:Journal Article
- MeSH:
Anti-Bacterial Agents;
administration & dosage;
pharmacology;
Calorimetry;
methods;
Ceftazidime;
administration & dosage;
pharmacology;
Cephradine;
administration & dosage;
pharmacology;
Escherichia coli;
drug effects;
growth & development;
metabolism;
Microbial Sensitivity Tests
- From:
Acta Pharmaceutica Sinica
2009;44(10):1127-1130
- CountryChina
- Language:Chinese
-
Abstract:
The effects of cephradinum and ceftazidime on the metabolism of Escherichia coli (E. coli) DH5alpha was determined by microcalorimetry. The microbial activity was recorded as power-time curves through an ampoule method with a TAM Air Isothermal Microcalorimeter at 37 degrees C. The parameters such as the growth rate constant (k), inhibitory ratio (I), the maximum power output (Pm) and the time (tm) corresponding to the maximum power output were calculated. The results show that the ceftazidime has a better inhibitory effect on E. coli DH5alpha than cephradinum.
