Synthesis and biological evaluation of 3-quinolinecarbonitrile-7-amide derivatives.
- Author:
Bao LIU
1
;
Qi-Dong YOU
;
Zhi-Yu LI
Author Information
1. Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
- Publication Type:Journal Article
- MeSH:
Aniline Compounds;
chemical synthesis;
chemistry;
pharmacology;
Antineoplastic Agents;
chemical synthesis;
chemistry;
pharmacology;
Cell Line, Tumor;
Humans;
Quinolines;
chemical synthesis;
chemistry;
pharmacology
- From:
Acta Pharmaceutica Sinica
2009;44(8):879-884
- CountryChina
- Language:Chinese
-
Abstract:
A series of N-(3-cyano-6-methyl-4-anilinoquinoline-7-yl) amide derivatives 13a-13n have been synthesized, their structures were confirmed with 1H NMR, EI-MS, IR and elemental analysis. Antitumor activities of all the synthesized compounds in vitro were tested with MTT. Compound 13j showed better than or equal antitumor activity on Bosutinib and EKB-569.
