LEDGF/p75: a novel target for anti-HIV therapy and advances in the study of its related inhibitors.
- Author:
Wen-Min CHEN
1
;
Xin-Yong LIU
Author Information
1. Institute of Medicinal Chemistry, School of Pharmacy, Shandong University, Jinan 250012, China.
- Publication Type:Journal Article
- MeSH:
Anti-HIV Agents;
chemistry;
pharmacology;
HIV Integrase;
metabolism;
HIV-1;
drug effects;
physiology;
Intercellular Signaling Peptides and Proteins;
metabolism;
Protein Binding
- From:
Acta Pharmaceutica Sinica
2009;44(9):953-960
- CountryChina
- Language:Chinese
-
Abstract:
LEDGF/p75 is a newly found cell cofactor, which plays an essential role in the integration of HIV-1 cDNA into host chromosomes. LEDGF/p75 tethers HIV integrase to chromatin, protects it from degradation, and strongly influences the genome-wide pattern of HIV integration. Depleting the protein from cells or over-expressing the integrase-binding domain of LEDGF/p75 blocks viral replication. The essential role of LEDGF/p75 in HIV-1 replication makes it a new target for anti-HIV-1 drug development. This article reviews the function of LEDGF/p75, LEDGF/p75-integrase interaction and LEDGF/p75 inhibitors.
