Effect of xiaoyin recipe in treatment of psoriasis patients of blood-heat syndrome type and its impact on peripheral Th1/Th2 equilibrium.
- Author:
Hong ZHANG
1
;
Xiao-guang XU
;
Jun GU
Author Information
- Publication Type:Clinical Trial
- MeSH: Adolescent; Adult; Aged; Case-Control Studies; Cytokines; blood; Drugs, Chinese Herbal; therapeutic use; Female; Humans; Male; Middle Aged; Psoriasis; blood; drug therapy; immunology; pathology; Th1 Cells; immunology; Th2 Cells; immunology; Young Adult
- From: Chinese Journal of Integrated Traditional and Western Medicine 2008;28(8):683-685
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the mechanism of Chinese medicinal therapy for cooling blood and removing stasis (CBRS) in treating psoriasis of blood-heat syndrome type by observing its clinical efficacy and impact on serum level of cytokines.
METHODSChanges of psoriasis area and severity index (PASI) scores, scores of syndrome and serum levels of tumor necrosis factor alpha (TNF-alpha, Th1 cytokine) and interleukin-10 (IL-10, Th2 cytokine) in 32 psoriatic patients before and after treatment were observed.
RESULTSThe total effective rate after 4 weeks of treatment and 8 weeks of treatment was 65.63% (21/32 cases) and 75.00% (24/32 cases) respectively. Scores of PASI and syndrome all improved after treatment (P < 0.05). And comparison of TNF-alpha level before and after treatment also showed significant difference (P < 0.05) , whereas that of IL-10 was insignificant (P > 0.05). Moreover, a positive correlation was found between PASI scores and secreting level of TNF-alpha in patients with psoriasis (r = 0.3709, P < 0.05).
CONCLUSIONChinese therapy for CBRS could play its effect in treating psoriasis by way of reducing TNF-alpha level.
