Effects of sphingosine 1-phosphate on functions of T cell - review.
- Author:
Wen-Rong HUANG
1
;
Li-Sheng WANG
;
Wan-Ming DA
Author Information
1. Department of Hematology, PLA General Hospital, Beijing 100853, China.
- Publication Type:Journal Article
- MeSH:
Fingolimod Hydrochloride;
Humans;
Immunosuppressive Agents;
pharmacology;
Lysophospholipids;
metabolism;
physiology;
Propylene Glycols;
pharmacology;
Receptors, Lysosphingolipid;
metabolism;
physiology;
Signal Transduction;
drug effects;
Sphingosine;
analogs & derivatives;
metabolism;
pharmacology;
physiology;
T-Lymphocytes;
drug effects;
immunology;
physiology
- From:
Journal of Experimental Hematology
2005;13(4):718-722
- CountryChina
- Language:Chinese
-
Abstract:
Sphingosine 1-phosphate (S1P), a bioactive lipid produced by metabolism of sphingolipid, plays an important roles in the regulation of various biological responses. T cell expresses the S1P receptors, including S1P1, S1P2, S1P3, S1P4 and S1P5. Activation of S1P signal regulates multiple immunological functions of T cell, including proliferation, apoptosis, differentiation, migration and cytokine excretion. FTY720, a sphingosine analog, suppresses the S1P signal resulting in redistribution of lymphocytes from circulation to secondary lymphoid tissues, which has been applied as a potent immunosuppressive drug. In this paper, biosythesis and degradation of S1P, S1P receptor and its mediated signal pathway, S1P receptor expression of T-cells, regulation of S1P on T cell functions and immunosuppresion drugs involving S1P signal pathway were reviewed.
