Survivin expression in midline T-cell lymphoma in relation to Epstin-Barr virus infection.
- Author:
Meng MING
1
;
Da-Bin WANG
;
Jian-Hua YI
;
Dian-Ding ZOU
;
Jun-Xia YAO
Author Information
1. Department of Pediatrics, Taihe Hospital, Yunyang Medical College, Shiyan 442000, China. mingmeng1992@yahoo.com.cn
- Publication Type:Journal Article
- MeSH:
Adaptor Proteins, Signal Transducing;
Adolescent;
Adult;
Aged;
Child;
Cytoskeletal Proteins;
Epstein-Barr Virus Infections;
metabolism;
pathology;
virology;
Female;
Granuloma, Lethal Midline;
metabolism;
pathology;
virology;
Humans;
Immunohistochemistry;
In Situ Hybridization;
Inhibitor of Apoptosis Proteins;
Intracellular Signaling Peptides and Proteins;
metabolism;
LIM Domain Proteins;
Lymphoma, T-Cell;
metabolism;
pathology;
virology;
Male;
Microtubule-Associated Proteins;
biosynthesis;
Middle Aged;
Neoplasm Proteins;
biosynthesis;
Nose Neoplasms;
metabolism;
pathology;
virology;
RNA, Viral;
genetics
- From:
Journal of Experimental Hematology
2005;13(5):815-818
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the expression of survivin gene and its relationship with Epstin-Barr virus (EBV) infection in midline T-cell lymphoma (MTL), immunohistochemistry staining method was used to examine the expression of survivin and EBV-latent membrane protein (LMP-1) in the 41 cases. In situ hybridization (ISH) was used to detect EBV-encoded RNA (EBER1/2). The results showed that the expression of survivin was positive in 26 cases of midline T-cell lymphoma, but no positive was detected in 10 cases of reactive lymphoid tissues. The positive expression ratio of survivin was 12.5% in cases of MTL with low grade of malignancy, and was 75.76% in cases of MTL with middle and high grades of malignancy, the significant difference was found between these two groups (chi(2) = 8.55, P < 0.01). Positive expression ratios of EBER1/2 and LMP-1 were 70.73% and 41.46% respectively. Survivin expression was not significantly different between EBER1/2 positive and negative cases (P > 0.05). It is concluded that survivin expression is up-regulated in MTL, and survivin positive expression rate is associated with the degree of malignancy. Survivin may play a role in the pathogenesis of the MTL by influencing cell apoptosis. EBV infection is not significantly associated with survivin expression in the MTL.
