Immunomodulation of bone marrow mesenchymal stem cells in hematopoietic stem cell transplantation--review.
- Author:
Lei GAO
1
;
Jian-Min WANG
Author Information
1. Department of Hematology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China.
- Publication Type:Journal Article
- MeSH:
Bone Marrow Cells;
cytology;
immunology;
Graft vs Host Disease;
immunology;
prevention & control;
Hematopoietic Stem Cell Transplantation;
Hematopoietic Stem Cells;
cytology;
immunology;
Humans;
Mesenchymal Stem Cell Transplantation;
Mesenchymal Stromal Cells;
cytology;
immunology;
Transplantation Immunology
- From:
Journal of Experimental Hematology
2005;13(5):907-910
- CountryChina
- Language:Chinese
-
Abstract:
Bone marrow mesenchymal stem cells (BM-MSC) have the characteristics of self-renewal and multipotency. They secrete a variety of cytokines and provided and ideal microenvironment for the division, proliferation and differentiation of hematopoietic stem cells (HSC) through the interaction with other stromal cells. Previous studies indicated that MSC could enhance engrafment and alleviate GVHD in allo-HSC and MSC co-transplantation. This effect on transplantation immunity may associate with escaping MHC compatible HSC from antigen recognition and suppressing activation and proliferation of nonspecific lymphocytes. In this paper, the characteristics of BM-MSC influencing transplantation immunity and its mechanism were reviewed.
