Folate receptor and its application in the selective receptor-mediated targeting therapy of tumor cells--review.
- Author:
Xiao-Ning GAO
1
;
Suo-Qin TANG
Author Information
1. Department of Pediatrics, The General Hospital of PLA, 100853 Beijing, China. gaoxn@tom.com
- Publication Type:Journal Article
- MeSH:
Antineoplastic Agents;
administration & dosage;
Carrier Proteins;
metabolism;
Drug Delivery Systems;
methods;
Folate Receptors, GPI-Anchored;
Folic Acid;
metabolism;
Humans;
Leukemia;
drug therapy;
metabolism;
pathology;
Receptors, Cell Surface;
metabolism;
Tretinoin;
administration & dosage;
Tumor Cells, Cultured
- From:
Journal of Experimental Hematology
2005;13(5):911-914
- CountryChina
- Language:Chinese
-
Abstract:
A series of receptors expressed in the surface of tumor cells, which are able to mediate internalizing effect by specially connecting with corresponding ligands. These receptors are potential targets for drugs combined with conjugates. So the drug-conjugate compounds can be targeted delivery to tumor cells. The folate receptor is a promising target because of its marrow tissue specificity, its overexpression in malignant tissues, especially in myeloid leukemic cells, and its ability to bind and internalize folic acid conjugates. It is a promising potential method to apply folate receptor in the receptor-mediated targeting therapy of leukemic cells. In this review, the biological features of folate receptor, its chromosome location and its interaction with ligands, the distribution characteristics of folate receptor in normal and tumor tissues, especially in myeloid leukemic cells, and progress of research on folate receptor mediated targeting tumor cells, especially leukemic cells were summarized.
