Expression and clinical significance of PTTG and b-FGF in acute leukemia.
- Author:
Jia CONG
1
;
Hong-Yi WANG
;
Cui-Ling ZHANG
Author Information
1. Department of Hemotology, The Affiliated Hospital, Medical College, Qingdao University, Qingdao 266003, China.
- Publication Type:Journal Article
- MeSH:
Acute Disease;
Adolescent;
Adult;
Aged;
Aged, 80 and over;
Antineoplastic Combined Chemotherapy Protocols;
therapeutic use;
Biomarkers, Tumor;
biosynthesis;
Child;
Female;
Fibroblast Growth Factor 2;
biosynthesis;
Humans;
Immunohistochemistry;
Leukemia;
drug therapy;
metabolism;
pathology;
Male;
Middle Aged;
Neoplasm Proteins;
biosynthesis;
Prognosis;
Securin
- From:
Journal of Experimental Hematology
2005;13(6):951-953
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the expression of pituitary tumor-transforming gene (PTTG) and basic fibroblast growth factor (b-FGF) in acute leukemia, as well as the relationship of their expression with prognosis in acute leukemia, expressions of PTTG and b-FGF in acute leukemia (AL) specimens were detected by immunocytochemical technique. The results showed that the expressions of PTTG and b-FGF in AL group were higher than that in the control group significantly (P < 0.01). In AL group, after chemotherapy, the expression of PTTG and b-FGF in de novo patients group was higher than in the complete remission patient group significantly (P < 0.01). The expressions of PTTG and b-FGF showed positive correlation (r = 0.61, P < 0.01). It is concluded that Up-regulation of PTTG and b-FGF expression may be involved in the progression of acute leukemia and correlated closely with therapeutic effect. Associated detection of PTTG and b-FGF may help to judge the malignancy degree and prognosis of acute leukemia.
