Effect of vitamin C antioxidative protection on human red blood cells.
- Author:
Tong ZAN
1
;
Jing TAO
;
Rong-Cai TANG
;
Yan-Chun LIU
;
Yi LIU
;
Bin HUANG
;
Jing-Yu ZHOU
;
Min-Hui WU
;
Hong-Li LIU
Author Information
1. Blood Center of Jiangsu Province, Nanjing 210042, China.
- Publication Type:Journal Article
- MeSH:
Adenosine Triphosphate;
blood;
Antioxidants;
pharmacology;
Ascorbic Acid;
pharmacology;
Blood Preservation;
methods;
Erythrocytes;
cytology;
drug effects;
metabolism;
Humans;
Malondialdehyde;
blood;
Potassium;
blood;
Superoxide Dismutase;
blood;
Time Factors
- From:
Journal of Experimental Hematology
2005;13(6):1106-1108
- CountryChina
- Language:Chinese
-
Abstract:
In order to investigate the effect of antioxidants on human blood, vitamin C was selected and added into plastic blood storage bags with CPD, and stored at 25 degrees C. During 6 days of storage, some indexes as ATP, SOD, MDA, K(+) concentration and superoxide radicals were detected and were compared with control group, The results showed that ATP and SOD activity in whole blood with vitamin C during 6 days of storage was higher then that in control group (P < 0.05, P < 0.01), the MDA and plasma K(+) concentrations in stored whole blood with vitamin C during 6 days of storage were lower than that in control group (P < 0.05, P < 0.01), the superoxide radical concentrations in stored whole blood with vitamin C decreased lower than that in control group (30%). The conclusion was made that vitamin C increases activities of ATP and SOD, decreases concentrations of MDA, plasma K(+) and superoxide radicals during blood preservation.
