Correlation between DNA load of human papillomavirus and recurrence of condyloma acuminata.
- Author:
Ya-min CHE
1
;
Jia-bi WANG
;
Ya-gang ZUO
;
Yue-hua LIU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Condylomata Acuminata; virology; DNA, Viral; analysis; Female; Humans; Male; Middle Aged; Papillomaviridae; genetics; isolation & purification; Papillomavirus Infections; virology; Recurrence; Sequence Analysis, DNA; Viral Load
- From: Acta Academiae Medicinae Sinicae 2004;26(5):558-561
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo determine the correlation between DNA load of human papillomavirus (HPV) and recurrence of condyloma acuminata (CA).
METHODSThe HPV6/11 and HPV16/18 DNA load of 31 cases of primary CA and 32 cases of recurrent CA were detected by real-time fluorogenic quantitative PCR.
RESULTSAmong the 63 CA patients, 62 cases were HPV6/11 DNA positive. The positive rate was 98.4%. The ranges of HPV6/11 DNA load in primary and recurrent CA were 1.4x10(3)-6.7x10(7) copies/ml and 1.2x10(4)-3.6x10(8) copies/ml respectively. Of 62 cases with HPV6/11 DNA positive, 7 cases were HPV16/18 DNA positive (11.3%). The ranges of HPV16/18 DNA load in primary and recurrent CA were 1.9x10(3)-1.6x10(4) copies/ml and 1.4x10(5)-1.7x10(7) copies/ml respectively. The HPV6/11 and HPV16/18 DNA load in recurrent CA were higher than in primary CA (P < 0.05). The DNA load of HPV6/11 was positively correlated with times of recurrence and course of disease (r=0.37 and 0.30 respectively).
CONCLUSIONCertain correlation exists between DNA load of HPV and recurrence of CA.
