Effect of combined continued hormone replacement therapy on knee osteoarthritis symptom of postmenopausal women.
- Author:
Yi-jun SONG
1
;
Shou-qing LIN
;
Zhi-hong WU
;
Xi-sheng WENG
;
Gui-xing QIU
;
Feng-ling CHEN
Author Information
- Publication Type:Clinical Trial
- MeSH: Aged; Double-Blind Method; Estradiol; therapeutic use; Estrogen Replacement Therapy; Female; Humans; Medroxyprogesterone Acetate; therapeutic use; Middle Aged; Osteoarthritis, Knee; drug therapy; Postmenopause; Prospective Studies
- From: Acta Academiae Medicinae Sinicae 2004;26(5):571-575
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effect of combined continued estrogen and progestin replacement therapy on knee osteoarthritis (OA) symptoms of postmenopausal women.
METHODSSixty-four postmenopausal women with radiological knee OA and symptoms aged 45-75 were divided into treatment group and control group. They were given estradiol velerate (E2V) 1.0 mg/d and medroxyprogestetone acetate (MPA) 2 mg/d (treatment group) or placebo (control group) for 6 months. Calcium 400 mg/d were given to all cases. Then 0-100 mm visual analon scale (VAS) was used to evaluate the severity of knee pain at baseline and after 1, 3, 6 month of treatment.
RESULTSSignificant differences on pain at night and tenderness around knee were seen in the treatment group compared with the control group after 1 months of treatment (P = 0.036 and 0.035, respectively). The improvement of pain at night, during walk and morning stiffness between the two groups showed significant difference after 6 months (P = 0.026, 0.027, and 0.011, respectively).
CONCLUSIONCombined estrogen and progestin replacement therapy can relieve the knee OA symptoms of postmenopausal women.
