Comparison of preemptive analgesia efficacy between etoricoxib and rofecoxib in ambulatory gynecological surgery.
- Author:
Wei LIU
1
;
C C LOO
;
H M TAN
;
Tie-Hu YE
;
Hong-Zhi REN
Author Information
- Publication Type:Journal Article
- MeSH: Abortion, Induced; adverse effects; Acetaminophen; therapeutic use; Adolescent; Adult; Ambulatory Surgical Procedures; Analgesics, Non-Narcotic; therapeutic use; Analgesics, Opioid; therapeutic use; Cyclooxygenase Inhibitors; therapeutic use; Double-Blind Method; Female; Fentanyl; therapeutic use; Humans; Lactones; therapeutic use; Pain Measurement; Pain, Postoperative; prevention & control; Preoperative Care; Pyridines; therapeutic use; Sulfones; therapeutic use
- From: Acta Academiae Medicinae Sinicae 2004;26(6):666-670
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo compare the preemptive analgesia efficacy between two cycloxygenase-2 inhibitors, rofecoxib and etoricoxib in the ambulatory uterine evacuation patients.
METHODSIn this randomized, double-blinded, placebo-controlled trial 60 patients were randomly divided into three groups and received a single dose of placebo, rofecoxib 50 mg, or etoricoxib 120 mg, respectively, before operation. Patient's visual analogue score (VAS) was rated postoperatively at 15 min, 30 min, 60 min, time-to-discharge, 6 h and 24 h. Fentanyl (in post-anesthesia care unit) and paracetamol (at home) were supplementary analgesics and the dosage was also recorded. Patient's satisfaction score was rated at 24 h postoperatively.
RESULTSEtoricoxib 120 mg and rofecoxib 50 mg were significantly superior to placebo at 6 h postoperatively (P < 0.05) while there was no significant differences of VAS at other time points. The amounts of Fentanyl used in post-anesthesia care unit were similar in three groups, but paracetamol taken at home was much less in rofecoxib group and etoricoxib group than in placebo group (P < 0.01). Compared to rofecoxib, etoricoxib provided better pain relief after discharge (P < 0.05). The overall pain management satisfaction score was significantly higher in etoricoxib group (96 +/- 7) than in other groups (P < 0.01).
CONCLUSIONPreemptive rofecoxib 50 mg and etoricoxib 120 mg may significantly decrease VAS at 6 h postoperatively, and reduce the usage of analgesics in ambulatory uterine evacuation patients. Etoricoxib 120 mg offeres better pain relief at home compared with rofecoxib 50 mg.