Gene expression of type X collagen in the intervertebral disc of idiopathic scoliosis patients.
- Author:
Qi LIN
1
;
Zhi-Hong WU
;
Yong LIU
;
Yi-Peng WANG
;
Xi-Sheng WENG
;
Jin LIN
;
Ye TIAN
;
Jian-Xiong SHEN
;
Hong ZHAO
;
Jian-Guo ZHANG
;
Gui-Xing QIU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Child; Collagen Type X; genetics; metabolism; Female; Gene Expression; Humans; Intervertebral Disc; metabolism; Male; Scoliosis; genetics; metabolism
- From: Acta Academiae Medicinae Sinicae 2004;26(6):696-699
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the characteristics of gene expression of type X collagen in the cartilage of end-plate and the fibrous annulus in the intervertebral disc of idiopathic scoliosis (IS) patients.
METHODInvestigating the expression of type X collagen in the peak disc and the lower end disc of 21 IS patients, the peak disc of 16 congenital scoliosis (CS) and the lumbar disc of 3 normal people (according with the principle of medical ethnics) by reverse transcript polymerase chain reaction.
RESULTSThe expression of type X collagen in the concave side of IS peak disc was higher than the convex side (P < 0.05). There was no significant difference of gene expression of type X collagen between the convex side and the concave side of the lower end disc (P > 0.05). The gene expression of type X collagen in the IS peak disc was higher than those of lower end disc (P < 0.05). For the CS peak discs, the expression of type X collagen of the concave side was higher than the convex side (P < 0.05).
CONCLUSIONThe expression of type X collagen of the IS peak disc increases, and the expression of type X collagen of the concave side is higher than the convex side. These changes may be secondary.
