Surgical management of brain-stem gliomas: a retrospective analysis of 311 cases.
- Author:
Chung-cheng WANG
1
;
Jun-ting ZHANG
;
A-li LIU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Astrocytoma; diagnosis; surgery; Brain Stem Neoplasms; diagnosis; surgery; Child; Child, Preschool; Ependymoma; diagnosis; surgery; Female; Follow-Up Studies; Glioblastoma; diagnosis; surgery; Humans; Infant; Magnetic Resonance Imaging; Male; Mesencephalon; surgery; Microsurgery; methods; Middle Aged; Neurosurgical Procedures; mortality; Pons; surgery; Retrospective Studies; Survival Rate
- From: Acta Academiae Medicinae Sinicae 2005;27(1):7-12
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo further study the clinical features, diagnosis, and surgery outcome of brain-stem gliomas.
METHODSTotally 311 patients with brain-stem gliomas received surgery operations in our hospital from 1980 to the end of 2001. The clinical data, neuroimages, growth patterns, and operative feasibility were analyzed.
RESULTSDifferent brain-stem gliomas showed different growth patterns. In this series, total excision rate of the tumor was 40.5%, subtotal 29.9%, partial 29.6%, and operative mortality 1.3%. Among 311 patients, 72.4% patients had been improved and stable in their symptoms after operation, and 27.6% deteriorated or having transitory new signs. Five years survival rate is 67% in ependymoma patients, 42% in astrocytoma patients. None of brain-stem glioblastoma patients survived up to 5 years.
CONCLUSIONSThe histology and growth pattern of brainstem gliomas varies. The patients with well-differentiated gliomas of brain-stem may be cured by microsurgical removal. For malignant ones, partial removal may prolong survival and facilitate the following combined therapy.
