Mechanisms of increased survival rate by administration of AG490 in rats following extensive liver resection.
- Author:
Yi-lei MAO
1
;
Zhuo YU
;
Xin LU
;
Xin-ting SANG
;
Zhi-ying YANG
;
Shou-xian ZHONG
Author Information
- Publication Type:Journal Article
- MeSH: Alanine Transaminase; blood; Animals; Aspartate Aminotransferases; blood; Bilirubin; blood; Blood Glucose; metabolism; Enzyme Inhibitors; pharmacology; Hepatectomy; methods; Male; Protein-Tyrosine Kinases; antagonists & inhibitors; Random Allocation; Rats; Rats, Sprague-Dawley; Survival Rate; Tyrphostins; pharmacology
- From: Acta Academiae Medicinae Sinicae 2005;27(1):73-76
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the mechanism by which AG490 improves the survival rate of rats following extensive liver resection.
METHODSThirty-eight rats were randomly divided into two groups after surgery: control group (n=10), without treatment; (2) AG490 group (n=28), with AG490 (1 mg x kg(-1) x 12 h(-1)) administrated intraperitoneally immediately and 36 hours after the operation. The survival rate was observed and the serum liver functions were measured.
RESULTSThe survival rates of control group and AG490 group were 0% and 25%. AG490 group had significantly better blood glucose and aminotransferase levels (P < 0.05) than control group; serum bilirubin levels significantly decreased 48 hours after the operation. Serum protein levels in both two groups had slow decrease but without statistical significance (P > 0.05).
CONCLUSIONSAG490 can significantly increase the survival rate of rats following extensive liver resection. Such a benefit mainly results from the protection towards residual liver function rather than from the promotion of liver regeneration.
