NQ01 gene polymorphism C609T associated with an increased risk for cognitive dysfunction and sporadic Alzheimer's disease in Chinese.
- Author:
Hua-ying WAN
1
;
Biao CHEN
;
Jing-fang YANG
;
Xiu-min DONG
Author Information
- Publication Type:Journal Article
- MeSH: Alzheimer Disease; genetics; Base Sequence; Cognition Disorders; genetics; Molecular Sequence Data; Mutation; NAD(P)H Dehydrogenase (Quinone); genetics; Polymerase Chain Reaction; Polymorphism, Genetic; Risk Factors; Sequence Analysis, DNA
- From: Acta Academiae Medicinae Sinicae 2005;27(3):285-288
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association between the C609T polymorphism of NADP (H): quinoneoxidoreductase 1 (NQ01) gene and decreased cognitive function and sporadic Alzheimer's disease (AD) in a community cohort.
METHODSPolymerase chain reaction (PCR), denaturing high performance liquid chromatography (DHPLC) and sequencing were used to determine the genotype of NQ01 in 110 subjects without cognitive dysfunction, 21 with cognitive dysfunction, and 65 AD patients from a community cohort.
RESULTSSignificantly different distributions of C/T and T/T genotypes were found between MMSE normal and abnormal subjects (OR=2.8, 95%CI 0.96-8.18, P=0.024), and between AD patients and healthy controls (OR=3.27, 95% CI 1.54-6.94, P=0.001), respectively. The frequencies of T allele of NQ01 C609T were significantly higher in MMSE abnormal subjects and AD patients (P=0.034 and 0.005) as compared to normal controls.
CONCLUSIONThe C609T polymorphism of NQ01 gene may be a genetic risk factor for cognitive dysfunction and sporadic AD in Chinese population.
