The significance of urine N-acetyl-beta-D-glucosaminidase in kidney injury with patients acute paraquat poisoning.
- Author:
Xu-bin SHI
1
;
Jun-ling HE
;
Yuang-qiang LU
Author Information
- Publication Type:Journal Article
- MeSH: Acetylglucosaminidase; urine; Acute Kidney Injury; chemically induced; diagnosis; Adolescent; Adult; Aged; Female; Humans; Male; Middle Aged; Paraquat; poisoning; Young Adult
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2013;31(3):223-224
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVESTo test the hypothesis that urine N-acetyl-beta-D-glucosaminidase (NAG) is a nearly biomarker for acute kidney injury in patients with acute paraquat poisoning.
METHODSForty-four patients with paraquat intoxication and 40 age and gender-matched healthy control participants were recruited. The urine N-acetyl-beta-D-glucosaminidase was determined by spectrophotometric methods.
RESULTSThe urine N-acetyl-beta-D-glucosaminidase activities in the patients with paraquat poisoning were higher than the corresponding values in the control participants (P<0.01); The prevalence rate of mortality was significantly higher in subjects with N-acetyl-beta-D-glucosaminidase activities ≥25 U/g Cr than in those N-acetyl-beta-D-glucosaminidase activities <25 Ulg Cr (34.4% vs 16.7%, P<0.01).
CONCLUSIONSThe urine N-acetyl-beta-D-glucosaminidase could be used as an early biomarker for acute kidney injury and predictor of mortality inpatients with acute paraquat intoxication.
